The prevalence of obesity varies among different racial groups. While obesity is apparent in no more than 30% of Chinese and Japanese patients with type 2 diabetes, it is present in 60–80% of North Americans, Europeans, or Africans with type 2 diabetes and approaches 100% of type 2 patients among Pima Indians or Pacific Islanders from Nauru or Samoa. Patients with type 2 diabetes have an insensitivity to endogenous insulin that is correlated with the presence of a predominantly abdominal distribution of fat, producing an abnormally high waist to hip ratio. In addition, distended adipocytes and overnourished liver and muscle cells may also resist the deposition of additional glycogen and … Continue reading Umesh Masharani, Michael S, German